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Inspirational Bicycle Quotes

first_imgAlex started biking when he was 5 and never let go of his passion. He first learned how to ride a bike in 3 days, and he has been mountain biking ever since. Believing that this is the best way to be fit and have a great mental state, he uses his bike everywhere. He is a tech entrepreneur and co-founder of 99bikereviews.com Does riding a bike make you a bit different from people who use other transportation methods? Some would argue that it doesn’t, but we think otherwise. Why is that? It is because riding is different from driving or flying a plane. You need to be a part of the bike in order to advance. As the great John Howard used to say “The bicycle is a curious vehicle. Its passenger is its engine”.It is not as demanding as snowboarding, or some other sport, and you can do it everyday for the rest of your life. People in Copenhagen, where the weather is cold, ride even when it is snowing. The upside would be the fact that you can stress your body when riding, and you can let your mind wonder freely at the same time. One example is Albert Einstein who famously wrote that he had thought of ideas and principles used in the book while riding his bicycle.This is a point that Elizabeth West was sure to make when saying that “When man invented the bicycle he reached the peak of his attainments. Here was a machine of precision and balance for the convenience of man. And (unlike subsequent inventions for man’s convenience) the more he used it, the fitter his body became. Here, for once, was a product of man’s brain that was entirely beneficial to those who used it, and of no harm or irritation to others. Progress should have stopped when man invented the bicycle. “But the sometimes stressed feeling you and I feel after a bad day at work has to clear out some time. You can either sleep or you can go and exercise a bit to get that weight off your shoulders. This was not a secret for Sir Arthur Conan Doyle.“When the spirits are low, when the day appears dark, when work becomes monotonous, when hope hardly seems worth having, just mount a bicycle and go out for a spin down the road, without thought on anything but the ride you are taking.” ~ Sir Arthur Conan DoyleHere are a few more inspirational quotes that refer to life as a bike ride:It never gets easier, you just go faster. ~ Greg LeMond.The journey of life is like a man riding a bicycle. We know he got on the bicycle and started to move. We know that at some point he will stop and get off. We know that if he stops moving and does not get off he will fall off. ~ William G. Golding EnglishWhenever I see an adult on a bicycle, I have hope for the human race. ~ H.G. WellsLet a man find himself, in distinction from others, on top of two wheels with a chain — at least in a poor country like Russia — and his vanity begins to swell out like his tires. ~ Leon TrotskyGet a bicycle. You will certainly not regret it, if you live. ~ Mark Twain Taming the Bicycle. 1884Melancholy is incompatible with bicycling. ~ James E. StarrsThe bicycle is just as good company as most husbands and, when it gets old and shabby, a woman can dispose of it and get a new one without shocking the entire community. ~ Ann StrongYou never have the wind with you — either it is against you or you’re having a good day. ~ Daniel BehrmanThink of bicycles as rideable art that can just about save the world. ~ Grant PetersenThe bicycle is the noblest invention of mankind. ~ William Saroyan Nobel prize winnerThe bicycle, the bicycle, surely should always be the vehicle of novelists and poets.~ Christopher Morely Nobel prize winnerBicycles are the indicator species of a community, like shellfish in a bay.~ P. Martin ScottWhoever invented the bicycle deserves the thanks of humanity. ~ Lord Charles BeresfordLife is like a ten speed bicycle. Most of us have gears we never use. ~ Charles M. Schulzlast_img read more

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Martinez content with Everton squad

first_imgEverton manager Roberto Martinez does not view the approaching transfer window as a priority as he believes he has assembled a squad good enough to cope without further additions in the second half of the campaign. “We will always work hard to try to see what we can do but it is not a priority in this window,” he said. “The priority was to make sure the summer window was exactly what we wanted and we achieved that. “I am very pleased with the squad – it is strong and good in numbers – and I don’t expect any major changes in January. “I am delighted because I measure the day-to-day work, what we have in the squad and the potential that I can see for the second half of the season.” Martinez, however, is expecting his players to rise to the challenge of a packed festive programme and give the club the ideal platform in which to target the top four in the new year, before the demands of the Europa League kick in again in February. They travel to Southampton, one of their rivals for a place in the top six, on Saturday before facing Stoke, Newcastle and Hull in quick succession. “The games we have now in the league are very important for us. It is probably a very important period for us to see what we do in the second half of the season. “The European competition has been a success and we will take that over in February but now all the concentration goes into the league. The Spaniard admits the coming weeks will have a significant bearing on how their season turns out but he is backing the players he has at his disposal to get them through. With midfielders James McCarthy, Darron Gibson and Leon Osman all close to a return after injury, and defender John Stones and striker Arouna Kone approaching full fitness after long spells on the sidelines, Martinez believes he has enough resources at his disposal. Press Association “I do feel this period of 12 days will be significant to see what we do in the second half of the season. “The group is getting stronger physically, the mentality has gone to another level and the only thing we can be critical about is we haven’t got the points we should have in the league. “That is something we need to learn. Sometimes it is a good knack to have as a team that you don’t have to be perfect to get full points and the top teams do that and I don’t think we have done that. “We had to be perfect every time to get the three points. That is something we need to work on and understand how to do it, but I have been very excited about the second half of the season because I can see something special building in the dressing room.” Martinez received some good news on the injury front with forward Kevin Mirallas expected to be sidelined for a couple of weeks at worst. On Monday the Belgium international was carried off on a stretcher after a poor tackle by Jordon Mutch having previously scored in the 3-1 win over QPR. “We have great news as we were very worried after the game because it was an action where you feel the ankle is definitely damaged,” said Martinez. “The damage is the least it could be. It is an external ligament in his ankle and the way he is as a quick healer I don’t expect him to be out for too long. “I wouldn’t rule him out for any of the fixtures over the Christmas period.” last_img read more

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3 things to know from this week in Syracuse athletics

first_img Published on February 7, 2016 at 8:33 pm Contact Connor: [email protected] | @connorgrossman Facebook Twitter Google+ Commentscenter_img 1. Syracuse men’s basketball continues hot streak through conference playA year after Michael Gbinije beat Virginia Tech at the buzzer, he rescued Syracuse again in a 68-60 overtime win on Tuesday. The veteran point guard hit an NBA-range 3-pointer to tie the game with 26 seconds remaining, and hit the first shot of overtime to give SU its first lead of the game. Freshman Tyler Lydon pitched into the winning effort despite foul trouble, and tallied 13 points off the bench.A three-game Atlantic Coach Conference winning streak has thrusted the Orange into the thick of the conference standings. It plays Florida State at home on Thursday at 7 p.m., then hits the road Sunday to play Boston College 1 p.m.MORE: What we learned from Syracuse basketball’s comeback win against Virginia TechEmma Comtois | Asst. Design EditorAdvertisementThis is placeholder text2. Dino Babers solidifies first recruiting class on National Signing DaySeventeen players pledged to Syracuse’s football team on Wednesday, when new head coach Dino Babers took the podium. Babers largely reshaped SU’s 20-person class, holding onto only four players that committed to the program under former head coach Scott Shafer. The new head coach’s recruiting efforts came to a head on the weekend of Jan. 22-24, when 12 players came on official visits to Syracuse’s campus. By the end of the 72-hour window, all 12 committed to the Orange.“It’s never happened to me in 31 years of coaching,” Babers said of the recruiting weekend bonanza.MORE: What to know about Syracuse’s class of 20163. Syracuse men’s lacrosse wins final preseason tuneup against No. 10 BrownAfter beating the Bears, 12-10, in a closed scrimmage on Saturday, the Orange is now on the doorstep of its season-opener against Siena on Saturday at 1 p.m. Head coach John Desko has refined his three starting lines that are featuring plenty of new faces compared to last year.Junior attack Jordan Evans flashed some acrobatic plays en route to his four points in the practice game, and even played some minutes at midfield as SU showcased a variety of offensive packages. Senior Dylan Donahue is expected to be the quarterback of the attack line that will also feature transfer Nick Piroli.MORE: Syracuse women’s lacrosse voted as ACC’s top teamQuick hits1. Briana Day and a trio of other starters led SU past the Yellow Jackets.2. Two members of Syracuse’s football team won’t be returning next year.2. Syracuse ice hockey is on a season-best winning streak.last_img read more

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Angels bullpen fails to hang on against Astros, spoiling Jaime Barria’s strong outing

first_imgPreviousHouston Astros’ Jose Altuve connects for a three-run double during the eighth inning of a baseball game against the Los Angeles Angels on Tuesday, May 15, 2018, in Anaheim, Calif. (AP Photo/Jae C. Hong)Los Angeles Angels’ Justin Upton swings for a two-run home run during the first inning of a baseball game against the Houston Astros on Tuesday, May 15, 2018, in Anaheim, Calif. (AP Photo/Jae C. Hong) SoundThe gallery will resume insecondsHouston Astros starting pitcher Gerrit Cole stands on the mound as Los Angeles Angels’ Justin Upton, background left, rounds the bases after hitting a two-run home run during the first inning of a baseball game Tuesday, May 15, 2018, in Anaheim, Calif. (AP Photo/Jae C. Hong)Los Angeles Angels’ Justin Upton celebrates his two-run home run as he returns to the dugout during the first inning of the team’s baseball game against the Houston Astros on Tuesday, May 15, 2018, in Anaheim, Calif. (AP Photo/Jae C. Hong)Los Angeles Angels starting pitcher Jaime Barria throws against the Houston Astros during the first inning of a baseball game Tuesday, May 15, 2018, in Anaheim, Calif. (AP Photo/Jae C. Hong)Houston Astros starting pitcher Gerrit Cole throws against the Los Angeles Angels during the first inning of a baseball game Tuesday, May 15, 2018, in Anaheim, Calif. (AP Photo/Jae C. Hong)Los Angeles Angels’ Mike Trout reacts after striking out during the third inning of the team’s baseball game against the Houston Astros on Tuesday, May 15, 2018, in Anaheim, Calif. (AP Photo/Jae C. Hong)Houston Astros starting pitcher Gerrit Cole throws to a Los Angeles Angels batter during the first inning of a baseball game Tuesday, May 15, 2018, in Anaheim, Calif. (AP Photo/Jae C. Hong)Los Angeles Angels starting pitcher Jaime Barria throws to a Houston Astros batter during the first inning of a baseball game Tuesday, May 15, 2018, in Anaheim, Calif. (AP Photo/Jae C. Hong)Los Angeles Angels’ Shohei Ohtani, right, watches as home plate umpire Fieldin Culbreth, left, is tended to by a trainer after Culbreth was struck by a foul ball hit by Ohtani during the third inning of the Angels’ baseball game against the Houston Astros on Tuesday, May 15, 2018, in Anaheim, Calif. (AP Photo/Jae C. Hong)ANAHEIM, CA – MAY 15: Shohei Ohtani #17 of the Los Angeles Angels of Anaheim checks his bat during an at bat during the third inning of a game against the Houston Astros at Angel Stadium on May 15, 2018 in Anaheim, California. (Photo by Sean M. Haffey/Getty Images)Los Angeles Angels designated hitter Shohei Ohtani, of Japan, talks to catcher Rene Rivera in the dugout during the first inning of a baseball game against the Houston Astros Tuesday, May 15, 2018, in Anaheim, Calif. (AP Photo/Jae C. Hong)ANAHEIM, CA – MAY 15: Justin Upton #8 of the Los Angeles Angels of Anaheim hits a two-run homerun as Brian McCann #16 of the Houston Astros looks on during the first inning of a game at Angel Stadium on May 15, 2018 in Anaheim, California. (Photo by Sean M. Haffey/Getty Images)Houston Astros’ Carlos Correa struggles with a single hit by Los Angeles Angels’ Andrelton Simmons during the first inning of a baseball game Tuesday, May 15, 2018, in Anaheim, Calif. (AP Photo/Jae C. Hong)Los Angeles Angels’ Andrelton Simmons slides into second base as Houston Astros’ Carlos Correa holds the ball in his glove during the first inning of a baseball game Tuesday, May 15, 2018, in Anaheim, Calif. Simmons was out on the steal attempt. (AP Photo/Jae C. Hong)Los Angeles Angels’ Andrelton Simmons hits a single during the fourth inning of a baseball game against the Houston Astros Tuesday, May 15, 2018, in Anaheim, Calif. (AP Photo/Jae C. Hong)Los Angeles Angels’ Andrelton Simmons watches after hitting a single during the fourth inning of a baseball game against the Houston Astros Tuesday, May 15, 2018, in Anaheim, Calif. (AP Photo/Jae C. Hong)Houston Astros’ Alex Bregman catches a foul ball hit by Los Angeles Angels’ Shohei Ohtani during the third inning of a baseball game Tuesday, May 15, 2018, in Anaheim, Calif. (AP Photo/Jae C. Hong)Los Angeles Angels’ Rene Rivera rounds the bases after hitting a home run during the fifth inning of a baseball game against the Houston Astros Tuesday, May 15, 2018, in Anaheim, Calif. (AP Photo/Jae C. Hong)Houston Astros starting pitcher Gerrit Cole stands on the mound after giving up a home run to Los Angeles Angels’ Rene Rivera, rear, during the fifth inning of a baseball game Tuesday, May 15, 2018, in Anaheim, Calif. (AP Photo/Jae C. Hong)Los Angeles Angels’ Rene Rivera, left, celebrates his home run with Mike Trout during the fifth inning of the team’s baseball game against the Houston Astros on Tuesday, May 15, 2018, in Anaheim, Calif. (AP Photo/Jae C. Hong)ANAHEIM, CA – MAY 15: Manager Mike Scioscia, Justin Upton #8 and Kole Calhoun #56 congratulate Rene Rivera #44 of the Los Angeles Angels of Anaheim after his solo homerun during the fifth inning of a game against the Houston Astros at Angel Stadium on May 15, 2018 in Anaheim, California. (Photo by Sean M. Haffey/Getty Images)Angels starting pitcher Jaime Barria throws to the plate during the second inning of Tuesday’s game against the Houston Astros at Angel Stadium. Barria allowed one run and four hits in seven innings, striking out seven. (Photo by Sean M. Haffey/Getty Images)Houston Astros’ Carlos Correa takes off his helmet after striking out as Los Angeles Angels catcher Rene Rivera heads toward the dugout after the top of the sixth inning of a baseball game Tuesday, May 15, 2018, in Anaheim, Calif. (AP Photo/Jae C. Hong)ANAHEIM, CA – MAY 15: Andrelton Simmons #2 of the Los Angeles Angels of Anaheim reacts to turning a double play during the second inning of a game against the Houston Astros at Angel Stadium on May 15, 2018 in Anaheim, California. (Photo by Sean M. Haffey/Getty Images)ANAHEIM, CA – MAY 15: Gerrit Cole #45 of the Houston Astros pitches during the second inning of a game against the Los Angeles Angels of Anaheim at Angel Stadium on May 15, 2018 in Anaheim, California. (Photo by Sean M. Haffey/Getty Images)ANAHEIM, CA – MAY 15: Alex Bregman #2 is congratulated in the dugout after scoring on an RBI single by Brian McCann #16 of the Houston Astros during the fourth inning of a game against the Los Angeles Angels of Anaheim at Angel Stadium on May 15, 2018 in Anaheim, California. (Photo by Sean M. Haffey/Getty Images)ANAHEIM, CA – MAY 15: Jaime Barria #51 of the Los Angeles Angels of Anaheim looks on during the second inning of a game against the Houston Astros at Angel Stadium on May 15, 2018 in Anaheim, California. (Photo by Sean M. Haffey/Getty Images)ANAHEIM, CA – MAY 15: Shohei Ohtani #17 of the Los Angeles Angels of Anaheim hits a single during the fifth inning of a game against the Houston Astros at Angel Stadium on May 15, 2018 in Anaheim, California. (Photo by Sean M. Haffey/Getty Images)ANAHEIM, CA – MAY 15: Los Angeles Angels of Anaheim fans hold signs in support of Shohei Ohtani #17 of the Los Angeles Angels of Anaheim during the third inning of a game against the Houston Astros at Angel Stadium on May 15, 2018 in Anaheim, California. (Photo by Sean M. Haffey/Getty Images)ANAHEIM, CA – MAY 15: Evan Gattis #11 of the Houston Astros reacts to flying out during the seventh inning of a game against the Los Angeles Angels of Anaheim at Angel Stadium on May 15, 2018 in Anaheim, California. (Photo by Sean M. Haffey/Getty Images)Houston Astros’ Carlos Correa takes off his helmet after striking out as Los Angeles Angels catcher Rene Rivera heads toward the dugout after the top of the sixth inning of a baseball game Tuesday, May 15, 2018, in Anaheim, Calif. (AP Photo/Jae C. Hong)Los Angeles Angels’ Ian Kinsler, right, is tagged out by Houston Astros catcher Brian McCann while trying to score on a single hit by Kole Calhoun during the seventh inning of a baseball game Tuesday, May 15, 2018, in Anaheim, Calif. (AP Photo/Jae C. Hong)ANAHEIM, CA – MAY 15: Umpire CB Bucknor calls out Ian Kinsler #3 of the Los Angeles Angels of Anaheim on the tag by Brian McCann #16 of the Houston Astros during the seventh inning of a game at Angel Stadium on May 15, 2018 in Anaheim, California. (Photo by Sean M. Haffey/Getty Images)Houston Astros’ Jose Altuve follows through on a three-run double during the eighth inning of a baseball game against the Los Angeles Angels Tuesday, May 15, 2018, in Anaheim, Calif. (AP Photo/Jae C. Hong)ANAHEIM, CA – MAY 15: Alex Bregman #2 of the Houston Astros slides safely at home as Rene Rivera #44 of the Los Angeles Angels of Anaheim awaits the throw during the eighth inning of a game at Angel Stadium on May 15, 2018 in Anaheim, California. (Photo by Sean M. Haffey/Getty Images)ANAHEIM, CA – MAY 15: Josh Reddick #22 congratulates Alex Bregman #2 after he scored on a three-run RBI double hit by Jose Altuve #27 of the Houston Astros as Jose Alvarez #48 of the Los Angeles Angels of Anaheim looks on during the eighth inning of a game at Angel Stadium on May 15, 2018 in Anaheim, California. (Photo by Sean M. Haffey/Getty Images)ANAHEIM, CA – MAY 15: Alex Bregman #2 congraulates Josh Reddick #22 in the dugout after scoring on a three-run RBI double hit by Jose Altuve #27 of the Houston Astros during the eighth inning of a game against the Los Angeles Angels of Anaheim at Angel Stadium on May 15, 2018 in Anaheim, California. (Photo by Sean M. Haffey/Getty Images)Los Angeles Angels’ Kole Calhoun throws the ball to first base during the eighth inning of a baseball game against the Houston Astros Tuesday, May 15, 2018, in Anaheim, Calif. (AP Photo/Jae C. Hong)Houston Astros’ Jose Altuve, right, slides into home plate against Los Angeles Angels catcher Rene Rivera in an unsuccessful attempt to score on a fielder’s choice during the eighth inning of a baseball game Tuesday, May 15, 2018, in Anaheim, Calif. (AP Photo/Jae C. Hong)Houston Astros’ Jose Altuve, left, is tagged out by Los Angeles Angels catcher Rene Rivera during the eighth inning of a baseball game Tuesday, May 15, 2018, in Anaheim, Calif. (AP Photo/Jae C. Hong)Houston Astros’ Jose Altuve, bottom, slides past home plate umpire CB Bucknor after he was tagged out by Los Angeles Angels catcher Rene Rivera during the eighth inning of a baseball game Tuesday, May 15, 2018, in Anaheim, Calif. (AP Photo/Jae C. Hong)Los Angeles Angels relief pitcher Jim Johnson can’t make the catch on a throw to first during the ninth inning of a baseball game against the Houston Astros Tuesday, May 15, 2018, in Anaheim, Calif. Josh Reddick was safe at first. (AP Photo/Jae C. Hong)Houston Astros’ Josh Reddick, left, and Los Angeles Angels relief pitcher Jim Johnson collide as Reddick reaches first base on a catch error by Johnson during the ninth inning of a baseball game Tuesday, May 15, 2018, in Anaheim, Calif. (AP Photo/Jae C. Hong)ANAHEIM, CA – MAY 15: Carlos Correa #1, George Springer #4 and Josh Reddick #22 of the Houston Astros celebrate defeating the Los Angeles Angels of Anaheim 5-3 in a game at Angel Stadium on May 15, 2018 in Anaheim, California. (Photo by Sean M. Haffey/Getty Images)Houston Astros’ Jose Altuve connects for a three-run double during the eighth inning of a baseball game against the Los Angeles Angels on Tuesday, May 15, 2018, in Anaheim, Calif. (AP Photo/Jae C. Hong)NextShow Caption1 of 45Houston Astros’ Jose Altuve connects for a three-run double during the eighth inning of a baseball game against the Los Angeles Angels on Tuesday, May 15, 2018, in Anaheim, Calif. (AP Photo/Jae C. Hong)ExpandANAHEIM — After their heartbreaking 5-3 loss to the Houston Astros on Tuesday night, the Angels turned their frustration toward José Altuve.José Álvarez had thrown a slider to Altuve that was down, probably not even in the strike zone, and Altuve did what few other players can do. He practically picked it out of the dirt and yanked it down the left-field line for a game-changing three-run double.“Altuve can hit everything,” catcher René Rivera said. “That’s a great player. He’s the MVP because of everything he can do up there. That pitch was down in the zone and off the plate. Sometimes you gotta tip your hat.”The hat-tipping to Altuve spoiled what should have been a night to celebrate Angels rookie starter Jaime Barría, who had pitched seven outstanding innings while allowing one run on four hits. But it didn’t go so well.Sign up for Home Turf and get 3 exclusive stories every SoCal sports fan must read, sent daily. Subscribe here.He fell behind left-handed hitting Josh Reddick and missed with a 3-and-1 fastball, which Reddick hit into right-center for a double. Álvarez threw a 1-and-2 changeup off the plate away from pinch-hitter Yuli Gurriel, a righty, who singled into right, sending Reddick to third.At that point, the Astros had their four best hitters, all righties, due. Righty Cam Bedrosian was warming in the bullpen. Álvarez stayed in the game.Álvarez got George Springer on a fly ball to shallow right, not deep enough to score the run. He then walked Alex Bregman, despite getting ahead 0-and-2, to load the bases. He got ahead of Altuve, 0-and-2, but couldn’t put him away either.“If it’s another hitter, maybe he misses or rolls over,” Álvarez said. “He’s a good hitter. It was a good pitch. Nothing you can say about it.”Álvarez added that it was “just a bad game. I tried to hold the game there. Things went out of hand. I took the loss. I feel bad about it. Tomorrow is another day.”His performance cost Barría on a day that he could not have been much better. He struck out seven and did not walk any.“He threw the ball great,” Rivera said. “That’s a real good lineup and he kept them off balance and used all his pitches. He did a great job in seven innings.”Barría struck out Carlos Correa twice, each time with two outs and a runner on base. He got him swinging through a 92 mph fastball above the strike zone in the sixth. He also fanned Marwin Gonzalez three times, the last time on a nice changeup that dropped off the table.He worked through a perfect seventh, ending his night by continuing the Angels’ impressive run of starting pitching. It was the 15th straight game that the Angels’ starter allowed three runs or fewer.After Andrew Heaney gave up one run in eight innings, it was the second straight night the Angels’ starter had outpitched his counterpart from the Astros, whose rotation is considered the best in the majors.Related Articles Jose Suarez’s rocky start sinks Angels in loss to Astros Angels offense breaks out to split doubleheader with Astros Barría, in fact, had outpitched Houston’s Gerrit Cole, who was knocked out after allowing three runs in five innings.All the Angels needed for Barría to notch a victory against Cole were six outs from the bullpen, with a 3-1 lead.Barría had finished with 96 pitches after the seventh. Considering that he hadn’t thrown more than 89 this year, or 97 at any point in at least the last three seasons, it was understandable for Manager Mike Scioscia to go to his bullpen.Also, he had Álvarez, a lefty, fresh off four days worth of “recharge” rest, with two lefties due to start the eighth. Álvarez also carried a 1.47 ERA to the mound.“José is one of our most reliable guys down there, against righties or lefties,” Scioscia said. “He has good stuff to go against righties, a really good changeup.” Angels’ Shohei Ohtani spending downtime working in outfield Clippers, Mavericks brace for the unknown in Game 4 Mike Trout, with bat and glove, helps Angels end losing streak Cole came into the game with a steak of 36 straight innings without allowing a homer, but the Angels took care of that quickly.Justin Upton blasted a two-run homer in the first inning, his seventh homer in May and 11th of the season. Upton’s 21 RBIs in May lead the majors.The Angels didn’t do much after that until Rivera blasted a first-pitch fastball from Cole out toward the rocks in center field, a 423-foot solo homer. Rivera’s third homer of the year put the Angels up 3-1. Reddick cost the Angels a chance at some insurance twice. The Astros right fielder threw Mike Trout out at third to end the fifth, and he nailed Ian Kinsler at the plate in the seventh.“He made two great throws,” Scioscia said. “We’ll stay aggressive on the base paths. We’ll try to keep pressing.” Newsroom GuidelinesNews TipsContact UsReport an Errorlast_img read more

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Lisa Booth Herring’s sports memorabilia auction on Wednesday

first_img Close Forgot password? Please put in your email: Send me my password! Close message Login This blog post All blog posts Subscribe to this blog post’s comments through… RSS Feed Subscribe via email Subscribe Subscribe to this blog’s comments through… RSS Feed Subscribe via email Subscribe Follow the discussion Comments Logging you in… Close Login to IntenseDebate Or create an account Username or Email: Password: Forgot login? Cancel Login Close WordPress.com Username or Email: Password: Lost your password? Cancel Login Dashboard | Edit profile | Logout Logged in as Admin Options Disable comments for this page Save Settings You are about to flag this comment as being inappropriate. Please explain why you are flagging this comment in the text box below and submit your report. The blog admin will be notified. Thank you for your input. There are no comments posted yet. Be the first one! Post a new comment Enter text right here! Comment as a Guest, or login: Login to IntenseDebate Login to WordPress.com Login to Twitter Go back Tweet this comment Connected as (Logout) Email (optional) Not displayed publicly. Name Email Website (optional) Displayed next to your comments. Not displayed publicly. If you have a website, link to it here. Posting anonymously. Tweet this comment Submit Comment Subscribe to None Replies All new comments Comments by IntenseDebate Enter text right here! Reply as a Guest, or login: Login to IntenseDebate Login to WordPress.com Login to Twitter Go back Tweet this comment Connected as (Logout) Email (optional) Not displayed publicly. Name Email Website (optional) Displayed next to your comments. Not displayed publicly. If you have a website, link to it here. Posting anonymously. Tweet this comment Cancel Submit Comment Subscribe to None Replies All new comments Click here for larger version of picture below. Follow us on Twitter.last_img read more

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Powerful CRISPR cousin accidentally mutates RNA while editing DNA target

first_imgJoung, a pioneering developer of base editors, was startled by the RNA changes, which had cytosines being converted to uracil, an RNA base that’s related to thymine. “When a postdoc first showed me the results and we saw tens of thousands of RNA cytosines being edited, I was like, ‘Wait a minute, what are we looking at here?’”Jia Chen, who does genome editing research at ShanghaiTech University in China and was not involved in the new work, was not as surprised, noting that deaminases were originally described as having the ability to alter RNA. But he says the new work will push the field to solve the problem. “The finding will [lead to] developing novel base editors with higher editing precision,” Chen says.Joung says his lab’s recent discovery of the old deaminase literature is what led his lab to do these experiments. And they’ve already engineered deaminases that substantially reduce the number of inadvertent RNA edits. “That was very encouraging to us,” Joung says. “We’re ultimately protein engineers, and we want to figure out if we can engineer the system to make the mutations go away.”David Liu, a Harvard University chemist who created the first base editor and co-founded two companies based on the technology with Joung, notes that deaminases naturally edit cellular RNA, stressing that the biological consequences of such editing are unclear. He adds that his own lab’s studies of base editors have also found RNA off-target edits, but at far lower levels. The differences between their results, says Liu, likely have less to do with the amount of off-target RNA editing that takes place than the different way Joung’s group sorted its cells and analyzed the results.Both Liu and Joung stress that their labs have found deaminases that work only on either DNA or RNA, which makes them confident that they can decouple the off-target effects seen with the current base editors. “Base editors are still incredibly powerful tools,” Joung says. “This is just another parameter we need to understand.” Country * Afghanistan Aland Islands Albania Algeria Andorra Angola Anguilla Antarctica Antigua and Barbuda Argentina Armenia Aruba Australia Austria Azerbaijan Bahamas Bahrain Bangladesh Barbados Belarus Belgium Belize Benin Bermuda Bhutan Bolivia, Plurinational State of Bonaire, Sint Eustatius and Saba Bosnia and Herzegovina Botswana Bouvet Island Brazil British Indian Ocean Territory Brunei Darussalam Bulgaria Burkina Faso Burundi Cambodia Cameroon Canada Cape Verde Cayman Islands Central African Republic Chad Chile China Christmas Island Cocos (Keeling) Islands Colombia Comoros Congo Congo, the Democratic Republic of the Cook Islands Costa Rica Cote d’Ivoire Croatia Cuba Curaçao Cyprus Czech Republic Denmark Djibouti Dominica Dominican Republic Ecuador Egypt El Salvador Equatorial Guinea Eritrea Estonia Ethiopia Falkland Islands (Malvinas) Faroe Islands Fiji Finland France French Guiana French Polynesia French Southern Territories Gabon Gambia Georgia Germany Ghana Gibraltar Greece Greenland Grenada Guadeloupe Guatemala Guernsey Guinea Guinea-Bissau Guyana Haiti Heard Island and McDonald Islands Holy See (Vatican City State) Honduras Hungary Iceland India Indonesia Iran, Islamic Republic of Iraq Ireland Isle of Man Israel Italy Jamaica Japan Jersey Jordan Kazakhstan Kenya Kiribati Korea, Democratic People’s Republic of Korea, Republic of Kuwait Kyrgyzstan Lao People’s Democratic Republic Latvia Lebanon Lesotho Liberia Libyan Arab Jamahiriya Liechtenstein Lithuania Luxembourg Macao Macedonia, the former Yugoslav Republic of Madagascar Malawi Malaysia Maldives Mali Malta Martinique Mauritania Mauritius Mayotte Mexico Moldova, Republic of Monaco Mongolia Montenegro Montserrat Morocco Mozambique Myanmar Namibia Nauru Nepal Netherlands New Caledonia New Zealand Nicaragua Niger Nigeria Niue Norfolk Island Norway Oman Pakistan Palestine Panama Papua New Guinea Paraguay Peru Philippines Pitcairn Poland Portugal Qatar Reunion Romania Russian Federation Rwanda Saint Barthélemy Saint Helena, Ascension and Tristan da Cunha Saint Kitts and Nevis Saint Lucia Saint Martin (French part) Saint Pierre and Miquelon Saint Vincent and the Grenadines Samoa San Marino Sao Tome and Principe Saudi Arabia Senegal Serbia Seychelles Sierra Leone Singapore Sint Maarten (Dutch part) Slovakia Slovenia Solomon Islands Somalia South Africa South Georgia and the South Sandwich Islands South Sudan Spain Sri Lanka Sudan Suriname Svalbard and Jan Mayen Swaziland Sweden Switzerland Syrian Arab Republic Taiwan Tajikistan Tanzania, United Republic of Thailand Timor-Leste Togo Tokelau Tonga Trinidad and Tobago Tunisia Turkey Turkmenistan Turks and Caicos Islands Tuvalu Uganda Ukraine United Arab Emirates United Kingdom United States Uruguay Uzbekistan Vanuatu Venezuela, Bolivarian Republic of Vietnam Virgin Islands, British Wallis and Futuna Western Sahara Yemen Zambia Zimbabwe When researchers first reported 3 years ago that they had created base editors, a version of the powerful genome-editing tool CRISPR, excitement swirled around their distinct powers to more subtly alter DNA compared with CRISPR itself. But the weaknesses of base editors have become increasingly apparent, and a new study shows they can also accidentally mutate the strands of RNA that help build proteins or perform other key cellular tasks. Researchers say this could complicate developing safe therapies with the technology and hamper other research applications.Human diseases from sickle cell to Tay-Sachs are caused by a single mutation to one of the four DNA bases—adenine, guanine, cytosine, and thymine—and CRISPR has often had difficulty swapping out the bad actors. That’s in part because CRISPR cuts double-stranded DNA at targeted places and then relies on finicky cell repair mechanisms to do the heavy lifting of inserting a corrected DNA sequence for a mutation. Base editors, in contrast, chemically change one DNA base into another with enzymes called deaminases, which doesn’t require a cut or help from the cell.Base editors, which adapt key components of CRISPR to reach targeted places in the genome, have been shown to have many off-target effects on DNA. But until now, its effects on RNA, which contains three of the same bases as DNA, had escaped scrutiny. So J. Keith Joung, a pathologist and molecular biologist at the Massachusetts General Hospital in Boston, led a team that put base editors into human liver and kidney cells. Their finding: Deaminases can also alter RNA, the group reports today in Nature. The enzyme that gives a powerful tool known as a “base editor” the ability to change DNA also has an off-target effect on RNA (above). Email By Jon CohenApr. 17, 2019 , 4:10 PMcenter_img Sign up for our daily newsletter Get more great content like this delivered right to you! 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